GDC-2394 (Genentech) is an oral NLRP3 inflammasome inhibitor. The NLRP3 inflammasome is the best studied and most characterized inflammasome , with the protein playing a key role in the detection of inflammatory danger signals which are a hallmark of many inflammatory diseases. Hyperactivation of the NLRP3 has been implicated in the [...]
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Nov. 28, 2022
GDC-2394: an Oral NLRP3 Inflammasome Inhibitor
GDC-2394
oral NLRP3 inhibitor predicted human dose of 500 mg QD LLE opt. and tox. mitig. from prev. clin. Cand. J. Med. Chem. Genentech, South San Francisco, CA
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